{"id":39759,"date":"2025-02-13T08:29:55","date_gmt":"2025-02-13T00:29:55","guid":{"rendered":"https:\/\/www.physics.nus.edu.sg\/?p=39759"},"modified":"2025-02-18T13:52:41","modified_gmt":"2025-02-18T05:52:41","slug":"unraveling-the-dual-mode-impact-on-tension-gauge-tethers-mechanical-stability","status":"publish","type":"post","link":"https:\/\/www.physics.nus.edu.sg\/unraveling-the-dual-mode-impact-on-tension-gauge-tethers-mechanical-stability\/","title":{"rendered":"Unraveling the Dual-Mode Impact on Tension Gauge Tethers\u2019 Mechanical Stability"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu-pic-300x234.png\" alt=\"\" class=\"alignnone wp-image-39760\" width=\"967\" height=\"754\" srcset=\"https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu-pic-300x234.png 300w, https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu-pic-1024x797.png 1024w, https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu-pic-768x598.png 768w, https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu-pic.png 1336w\" sizes=\"(max-width: 967px) 100vw, 967px\" \/><\/p>\n<p>Dr. Jingzhun Liu and Prof. Jie Yan from NUS have made a groundbreaking discovery in the field of cellular mechanosensing and mechanotransduction, uncovering how mechanical forces are converted into biochemical signals within cells. Led by Prof. Yan, the team developed a simple yet powerful formula to predict the stability of Tension Gauge Tethers (TGTs)\u2014key tools for measuring molecular forces\u2014eliminating the need for time-consuming experimental calibrations. This breakthrough not only enhances our understanding of how cells sense and respond to mechanical stimuli but also opens new avenues for studying mechanobiology\u2019s role in health and disease. Their findings were published in the Journal of the American Chemical Society (Feb 2024).<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu_yanjie-300x192.jpg\" alt=\"\" class=\"alignnone wp-image-39818\" width=\"940\" height=\"602\" srcset=\"https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu_yanjie-300x192.jpg 300w, https:\/\/www.physics.nus.edu.sg\/wp-content\/uploads\/sites\/5\/2025\/02\/Jingzhun-Liu_yanjie.jpg 474w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Jingzhun Liu and Prof. Jie Yan from NUS have made a groundbreaking discovery in the field of cellular mechanosensing&#8230;<\/p>\n","protected":false},"author":77,"featured_media":39760,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[84],"tags":[],"class_list":["post-39759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nus-physics-breakthrough-of-the-year-2024"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/posts\/39759"}],"collection":[{"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/users\/77"}],"replies":[{"embeddable":true,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/comments?post=39759"}],"version-history":[{"count":10,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/posts\/39759\/revisions"}],"predecessor-version":[{"id":39821,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/posts\/39759\/revisions\/39821"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/media\/39760"}],"wp:attachment":[{"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/media?parent=39759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/categories?post=39759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.physics.nus.edu.sg\/wp-json\/wp\/v2\/tags?post=39759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}